Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Morphometric and histopathological studies on the effects of some chromatographic fractions of Phyllanthus amarus and Euphorbia hirta on the male reproductive organs of rats | J. Vet. Sci. 2003 4 2 181-185 HEQQ SHSIS Veterinary Science Morphometric and Histopathological Studies on the Effects of Some Chromatographic Fractions of PhyUanthus amarus and Euphorbia hirta on the Male Reproductive Organs of Rats A. A . Adedapo M. o. Abatan A. K . Akinloye s. Idowu and o. Olorunsogo Departments of Veterinary Physiology and Pharmacology Veterinary Anatomy 2Pharmaceutical Chemistry and 3Biochemistry. University of Ibadan Ibadan Nigeria Received February 4 2003 Accepted June 18 2003 Abstract The aqueous crude extracts of p. amarus and E. hirta were administered to thirty eight-week old sexually mature male albino to determine the effects of these extracts on the male reproductive organs of these animals. The results from this study revealed that the aqueous crude extracts of p. amarus and E. hirta caused varying degrees of testicular degeneration as well as reduction in the mean seminiferous tubular diameter STD in the treated rats. It thus shows that the aqueous crude extracts of p. amarus and E. hirta have potentially deleterious effects on the testes and accessory organs of rats. Great caution should therefore be exercised in the use of these plants for medicinal purpose. Key words morphometry histopathology Phyllanthus amarus E. hirta epididymis testes Introduction Phyllanthus amarus is a herb common from Sierra Leone to Southern Nigeria and Equatorial Guinea and widespread elsewhere in tropical Africa. It is a plant of general medicinal application. Phyllanthus amarus possesses activity against Hepatitis B virus and related hepadnaviruses. This plant is known to have the inhibitory effect on endogenous hepadnavirus DNA polymerase 13 16 20 28 29 30 31 . Recent biochemical pharmacological and clinical studies have confirmed and also extended the medicinal uses of species of genus Phyllanthus in traditional medicine 6 18 24 Potent analgesic from the methanolic extracts of callus culture in-vitro obtained from p. tenellus p. corcovadensis
