Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Hepatic cirrhosis occurring in a young woodchuck (Marmota monax) due to vertical transmission of woodchuck hepatitis virus (WHV) | J. Vet Sci. 2003 4 2 199-201 Veterinary Science - Short Communication - Hepatic Cirrhosis Occurring in a Young Woodchuck Marmota monax Due to Vertical Transmission of Woodchuck Hepatitis Virus WHV Da-hee Jeong Won-il Jeong Jae-yong Chung Mi-young An Chae-yong Jung Gyoung-jae Lee1 Jong-soo Kang1 Byeong-cheol Kang2 Young-heun Jee3 Bruce H Williams4 Young-oh Kwon5 and Kyu-shik Jeong College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea shinwon Scientific Co. LTD Research Institute Suwon Korea 2Clinical Research Institute Seoul National University Seoul 110-744 Korea 3College of Veterinary Medicine Jeju National University Jeju 690-756 Korea 4Department of Veterinary Pathology Armed Forces Institute of Pathology Washington DC 20306-6000 . 5College of Medicine Kyungpook National University Daegu 702-701 Korea Received April 11 2003 Accepted June 13 2003 Abstract Histologic and clinicopathologic findings of a woodchuck Marmota monax vertically infected with woodchuck hepatitis virus WHY are presented. The liver exhibits marked cirrhotic changes which is characteristic of the pre-transformation phase of WHY. At necropsy the woodchuck exhibited ascites and the liver had a grossly nodular appearance. Microscopically focal hepatocyte necrosis and inflammatory cells were observed in midzonal and periportal areas in the liver. In Macchiavellos stained sections cytoplasmic inclusion bodies appeared reddish granular materials. We believe that this may represent a new suitable and cost-effective cirrhotic model for the disease processes associated with hepadnaviruses in a number of other species most notably Hepatitis B virus infection in man. Key words hepatic cirrhosis woodchuck woodchuck hepatitis virus Chronic viral infection has been reported to cause a range of hepatic lesion including hepatic fibrosis cirrhosis and hepatocellular carcinoma HCC in a wide variety of animal species 14 In man Hepatitis B virus HBV is a pathogen that causes .
