Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Analgesic effect of caudal epidural ketamine in cattle | J. Vet. Sci. 2003 4 3 261-264 JOURNAL OF Veterinary Science Analgesic effect of caudal epidural ketamine in cattle Inhyung Lee Tomo Yoshiuchi1 Norio Yamagishi2 Kenji Oboshi2 Yu Ayukawa Naoki Sasaki and Haruo Yamada Department of Clinical Veterinary Science Obihiro University of Agriculture and Veterinary Medicine Inada Obihiro Hokkaido 080-8555 Japan 1 Prevention of Epidemics Section Kenou Animal Hygiene Service Center of Tochigi Prefecture Hiraide Utsunomiya Tochigi 321-0905 Japan Research Center for Animal Hygiene and Food Safety Obihiro University of Agriculture and Veterinary Medicine Inada Obihiro Hokkaido 080-8555 Japan This study was performed to clarify the analgesic effect of ketamine injected into the first intercoccygeal Co1-Co2 epidural space in standing cattle. Five adult cows were randomly received 3 treatments at least 1 week interval 5 10 and 20 mL of 5 ketamine. Sedation analgesia ataxia and other effects on cardiopulmonary and rumen functions were assessed before ketamine administration and until 120 min. The analgesia without sedation was shown at tail and perineum about 5 min after all three treatments. The duration of analgesia was significantly increased according to the volume of ketamine p . There was a similar tendency of ataxia with individual variation. There were minimal effects on cardiopulmonary and rumen functions. The present study showed that caudal epidural ketamine administration induced analgesia without sedation in cows and the duration of analgesia was dose dependent with ataxia. However the duration of analgesia after 5 and 10 mL ketamine administration is short for common surgical procedures and pain relief of perineum. Further studies are needed to prolong the duration of analgesia without side effects. Key words caudal epidural anesthesia ketamine analgesia cattle Introduction Caudal epidural anesthesia is simple and inexpensive and requires no sophisticated equipment 22 . It is routinely used in ruminants for .