Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Changes of gastrointestinal argyrophil endocrine cells in the osteoporotic SD rats induced by ovariectomy | J. Vet. Sci. 2004 5 3 183-188 JOURNAL OF Veterinary Science Changes of gastrointestinal argyrophil endocrine cells in the osteoporotic SD rats induced by ovariectomy Sae-Kwang Ku1 Hyeung-Sik Lee2 Jae-Hyun Lee3 Pharmacology Toxicology Lab. Central Research Laboratories Dong-Wha Pharm. Ind. Co. Anyang 430-017 Korea Department of Herbal Biotechnology Daegu Haany University Daegu 712-715 Korea Department of Histology College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea The regional distributions and frequencies of argyrophil endocrine cells in gastrointestinal GI tract of osteoporotic Sprague-Dawley rat induced by ovariectomy were studied using Grimelius silver stain. The experimental animals were divided into two groups one is non-ovariectomized group Sham and the other is ovariectomized group OVX . Samples were collected from each part of GI tract fundus pylorus duodenum jejunum ileum cecum colon and rectum at 10th week after ovariectomy or sham operation. In this study argyrophil cells were detected throughout the entire GI tract with various frequencies regardless of ovariectomy. Most of these argyrophil cells in the mucosa of GI tract were generally spherical or spindle in shape open type cell while cells showing round in shape close type cell were found occasionally in gastric and or intestinal gland regions. The regional distributions of GI argyrophil endocrine cells in OVX were similar to those of Sham. However significant decreases of argyrophil cells were detected in OVX compared to those of Sham except for the pylorus jejunum and cecum. In pylorus and jejunum argyrophil cells in OVX dramatically decreased compared to those of Sham but significances were not recorded. In addition argyrophil cells in cecum of OVX showed similar frequency compared to that of Sham. The endocrine cells are the anatomical units responsible for the production of gut hormones that regulate gut motility and digestion including absorption and a change in .
