Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat | J. Vet. Sci. 2004 5 3 189-195 JOURNAL OF Veterinary Science Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat Jeoung-Woo Kang1 Tae-Wan Kim2 Jun-Ho La1 Tae-Sik Sung1 Hyun-Ju Kim1 Young-Bae Kwon3 Jeum-Yong Kim3 Il-Suk Yang1 Department of Physiology College of Veterinary Medicine Seoul National University Seoul 151-742 Korea Department of Physiology College of Veterinary Medicine Kyungpuk National University Daegu 712-715 Korea Institute of Bioscience and Biotechnology Daewoong Pharm Co. LTD. Yongin 449-814 Korea The effect of electroacupuncture EA on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4 acetic acid. EA 2 Hz ms 2 V for 20 min was applied to bilateral Hoku LI-4 and Zusanli ST-36 on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility. However colonic motility of EA-treated group was not significantly different from that of normal group. The anti-inflammatory effect of EA was not inhibited by a glucocorticoid receptor antagonist RU-486 but suppressed by a P-adrenoceptor antagonist propranonol. These results suggest that EA-treatment has a beneficial effect on colitis and its anti-inflammatory effect is mediated by P-adrenoceptor activation but not by endogenous glucocorticoiddependent mechanism. Key words colitis electroacupuncture glucocorticoid P-adrenoceptor Introduction Inflammatory bowel disease IBD is a chronic inflammatory disorder with unknown etiology and pathogenesis. In patients with IBD gut inflammation is associated with intestinal muscle dysfunction 25 34 . These observations have been confirmed in a variety of animal models of experimental intestinal inflammation 9 18 showing that smooth muscle dysfunction is linked to the inflammatory reaction. .