Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Application of biotechnological tools for coccidia vaccine development | J. Vet. Sci. 2004 5 4 279-288 JOURNAL OF Review Veterinary Science Application of biotechnological tools for coccidia vaccine development Wongi Min1 2 Rami A. Dalloul1 Hyun S. Lillehoj1 1Animal Parasitic Diseases Laboratory Animal and Natural Resources Institute U. S. Department of Agriculture Beltsville MD. 20705 USA Department of Animal Science Technology Sunchon National University Suncheon 540-742 Korea Coccidiosis is a ubiquitous intestinal protozoan infection of poultry seriously impairing the growth and feed utilization of infected animals. Conventional disease control strategies have relied on prophylactic medication. Due to the continual emergence of drug resistant parasites in the field and increasing incidence of broiler condemnations due to coccidia novel approaches are urgently needed to reduce economic losses. Understanding the basic biology of hostparasite interactions and protective intestinal immune mechanisms as well as characterization of host and parasite genes and proteins involved in eliciting protective host responses are crucial for the development of new control strategy. This review will highlight recent developments in coccidiosis research with special emphasis on the utilization of cutting edge techniques in molecular cell biology immunology and functional genomics in coccidia vaccine development. The information will enhance our understanding of host-parasite biology mucosal immunology and host and parasite genomics in the development of a practical and effective control strategy against Eimeria and design of nutritional interventions to maximize growth under the stress caused by vaccination or infection. Furthermore successful identification of quantitative economic traits associated with disease resistance to coccidiosis will provide poultry breeders with a novel selection strategy for development of genetically stable coccidiosis-resistant chickens thereby increasing the production efficiency. Key words Chicken Eimeria coccidiosis .
