Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Cystic endometrial hyperplasia and endometritis in a dog following prolonged treatment of medroxyprogesterone acetate | J. Vet. Sci. 2005 6 1 81-82 JOURNAL OF Short Communication Veterinary Science Cystic endometrial hyperplasia and endometritis in a dog following prolonged treatment of medroxyprogesterone acetate Kyung-Suk Kim1 Okjin Kim2 3 1NYAnimal Hospital Anyang 431-065 Korea department of Laboratory Animal Sciences College of Medicine Seoul National University Seoul 110-799 Korea 3Center for Animal Resource Development Seoul National University Seoul 110-799 Korea An 8-year-old female Yorkshire Terrier was presented for investigation of reduced appetite and occasional vomiting. She has been treated with medroxyprogesterone acetate MPA from past 3 year-old age for contraception. Abdominal sonography showed abnormal enlargement of uterus and ovariohysterectomy was performed. Main gross findings of uterus were enlarged lesions in two areas of the left horn which had thickened wall and yellowish sticky material in the lumen. Histopathologically cystic endometrial hyperplasia CEH and endometritis were present in the thickened area. In this case CEH and endometritis may be attributed to prolonged treatment of MPA. It was concluded that further study is needed to clarify the association of MPA treatment with age its pathogenesis and abnormal uterine changes in dogs. Keywords dog cystic endometrial hyperplasia endometritis medroxyprogesterone Cystic endometrial hyperplasia CEH and pyometra in the bitch are dioestral syndromes supposed to be caused by hormonal disturbances and changes in endometrial steroid hormone receptor levels 3 . Histologically the endometria show cystic dilated glands and if bacteria succeed in invading the uterus pyometra may develop in the following metoestrus 2 . The occurrence of CEH has been reported in connection with the administration of progesterone-related contraceptives in cats and zoo animals 5 . In this report we described a case of CEH with endometritis in a bitch that had been treated with medroxyprogesterone acetate MPA progesterone derivative for
