Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Changes of gastrointestinal argyrophil endocrine cells in the COLO205 tumor-implanted Balb/c-nu/nu mice | J. Vet. Set. 2005 6 4 267-271 JOURNAL OF Veterinary Science Changes of gastrointestinal argyrophil endocrine cells in the COLO205 tumor-implanted Balb c-nu nu mice Sae-kwang Ku1 Seung-Kyoo Seong1 Hyeung-sik Lee2 Jae-hyun Lee3 1 Pharmacology Toxicology Lab. Central Research Laboratories Dong-Wha Pharm Anyang 430-017 Korea. 2Department of Herbal Biotechnology Daegu Haany University Daegu 712-715 Korea Department of Histology College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea The regional distributions and frequencies of argyrophil endocrine cells in gastrointestinal GI tract of Balb c-nu nu mouse were studied using Grimelius silver stain after abdominal subcutaneous implantation of COLO205. The experimental animals were divided into two groups one is non-implanted group Sham and the other is COLO205-implanted group. Samples were collected from GI tract fundus pylorus duodenum jejunum ileum cecum colon and rectum at 21 days after implantation of COLO205 cells 1X IO6 cell mouse . In this study argyrophil cells were detected throughout the entire GI tract with various frequencies regardless of implantation. Most of these argyrophil cells in the mucosa of GI tract were generally spherical or spindle in shape open type cell while cells showing round in shape close type cell were found occasionally in gastric and or intestinal gland regions. The regional distributions of argyrophil cells in COLO205 were similar to those of Sham. However significant decreases of argyrophil cells were detected in COLO205 compared to those of Sham except for the jejunum and ileum. In the jejunum and ileum argyrophil cells in COLO205 showed similar frequencies compared to those of Sham. In the pylorus the most dramatically decreasement of argyrophil cells were detected in COLO205 compared to that of Sham. Implantation of COLO205 tumor cell line induced severe quantitative changes of argyrophil cell density and the abnormality in density of GI endocrine cells may .
