Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice | J. Vet. Set. 2005 6 4 357-359 JOURNAL OF Short Communication Veterinary Science Experimental reproduction of proliferative enteropathy and the role of IFN-y in protective immunity against Lawsonia intracellularis in mice XT XT 1 X- XT- X lx XT XT 3 X XX 1 X XT XX 1 Z 1 1 Yun-Young Go Jeong-Keun Lee Jeong-Yong Ye Joong-Bok Lee Seung-Yong Park Chang-Seon Song Soo-Ki Kim 4 In-Soo Choi12 department oflnfectious Diseases College of Veterinary Medicine Konkuk University Seoul 143-701 Korea institute of Biomedical Science and Technology Konkuk University Seoul 143-701 Korea 3Foreign Animal Disease Division National Veterinary Research and Quarantine Service Anyang 430-016 Korea department of Animal Sciences and Environment College of Animal Husbandly Konkuk University Seoul 143-701 Korea Proliferative enteropathy was reproduced in IFN-y receptor knockout IFN-y R mice by experimental infection with Lawsonia intracellularis L. intracellularis . The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However high levels of IFN-y were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-y produced in the infected mice should have been utilized by it s receptor to elicit protective immune responses against L. intracellularis infections. Key words IFN-y R mice IFN-y Lawsonia intracellularis proliferative enteropathy Proliferative enteropathy PE is caused in pigs by infection with L. intracellularis the obligate intracellular Gramnegative bacterium 6 . Typical clinical signs of PE in pigs are diarrhea and growth retardation which eventually lead to a high economic loss in pig industry worldwide 4 9 . The characteristic of PE lesions in naturally infected pigs with L. intracellularis is proliferation of immature epithelial cells in the ileum 5 . A more severe form of PE is described as .
