Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog | J. Vet. Set. 2005 6 4 363-366 JOURNAL OF Case Report Veterinary Science A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog Young-Mi Lee Byeong-Teck Kang Dong-in Jung Chui Park Ha-Jung Kim Ju-Won Kim Chae-Young Lim Eun-Hee Park Hee-Myung Park Department of Veterinary Internal Medicine College of Veterinary Medicine Konkuk University Seoul 143-701 Korea Hyperadrenocorticism a disorder characterized by excessive production of cortisol by the adrenal cortex is well-recognized in dogs. A 10-year-old intact male Yorkshire terrier dog was evaluated because of corneal ulceration and generalized alopecia. Diagnosis was made based on history taking clinical signs physical examination and results of routine laboratory testing complete blood count serum biochemical analysis and urinalysis . In addition adrenocorticotropic hormone ACTH stimulation test and abdominal ultrasonography were also used to diagnose this case. The patient was diagnosed as adrenal gland neoplasia and medical therapy using the adrenocorticolytic agent mitotane was initiated. An ACTH stimulation test was performed after initial therapy. After successful induction was obtained maintenance therapy with mitotane still continued. Key words adrenal gland tumor dog hyperadrenocorticism Hyperadrenocorticism HAC is a common multi-systemic endocrine disorder in dogs 2 Approximately 85 of dogs with HAC results from excessive secretion of adrenocorticotropic hormone ACTH from pituitary gland. Adrenocortical neoplasia autonomously secretes an excessive quantity of cortisol independent of endogenous corticotropin control. Characteristics of HAC caused by an adrenal tumor include high baseline serum cortisol concentration that remain high during high dose dexamethasone testing low or low reference range values low-normal for plasma ACTH concentrations and a solitary unilateral adrenal mass as revealed by adrenal imaging studies 5 . Therapy in patient with adrenal .
