Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Concurrent response to challenge infection with Cryptosporidium parvum in immunosuppressed C57BL/6N mice | J. Vet. Set. 2006 7 1 47-51 JOURNAL OF Veterinary Science Concurrent response to challenge infection with Cryptosporidiumparvum in immunosuppressed C57BL 6N mice Chan-Gu Suri1 Hyeon-Cheol Kim2 1 College of Veterinary Medicine Chonbuk National University Jeonju 561-756 Korea 2College of Animal Resources Science Department of Veterinary Medicine Kangwon National University Chuncheon 200-701 Korea We investigated the response to challenge infection with Cryptosporidium parvum oocysts in immunosuppressed C57BL 6N mice. In the primary infection fecal oocyst shedding and parasite colonization were greater in immunosuppressed mice than in nonimmunosuppressed mice. Compared with primary infection challenge infection with c. parvum didn t show any oocyst shedding and parasite colonization. Especially oocyst shedding and parasite colonization from the mice infected with heat-killed oocysts were not detected. After challenge infection with c. parvum oocysts however these mice were shedding small numbers of oocysts and parasite colonization. Except normal control and uninfected groups the antibody titers of other groups appear similar. Based on the fecal oocyst shedding parasite colonization of ilea and antibody titers in the mice these results suggest that the resistance to challenge infection with c. part um in immunosuppressed C57BL 6N mice has increased. Key words antibody response Cryptosporidium parvum immunosuppression infection Introduction Since the first report of cryptosporidiosis in cattle in 1971 15 Cryptosporidium parvum has proven to be significantly important as a cause of neonatal diarrhea in most domesticated animals 21 c. parvum Apicomplexa Cryptosporididae is an intracellular protozoan parasite that colonizes in epithelial cells of the respiratory and digestive tracts in humans and other animals 5 11 14 The most severe consequence of human cryptosporidiosis occurs in the immunodeficient host and c. parvum is recognized as a significant opportunistic .
