Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury | J. Vet. Set. 2006 7 1 79-81 JOURNAL OF Veterinary Science Influence of ascorbic acid on BUN creatinine resistive index in canine renal ischemia-reperfusion injury Jae-il Lee1 Myung-jin Kim1 Chang-sik Park2 Myung-cheol Kim1 Laboratory of Veterinary Surgery College of Veterinary Medicine Chungnam National University Daejeon 305-764 Korea 2Division ofAnimal Science Resources Research Center for Transgenic Cloned Pigs Chungnam National University Daejeon 305-764 Korea Renal ischemia as a course of renal transplantation is a common cause of renal dysfunction as renal failure. The purpose of this study was to investigate the influence of ascorbic acid on blood urea nitrogen BUN creatinine Cr and resistive index RI for dog models with renal ischemia-reperfusion I R injury. Renal ischemia was induced on 6 Beagle dogs. The left kidney was exposed to normothermic ischemia for a short period at 30 min followed by reperfusion. On the blood Cr level and RI there was no significant difference comparing both groups. 14 days after I R injury a significant reduction on the blood BUN level was observed in the vehicle group mg dl compared to that of ischemia induced treated group mg dl p . In conclusion administration of ascorbic acid for renal ischemic-reperfusion injury had influence on blood BUN level but it was not revealed the influence on blood Cr and RI. Key words BUN creatinine dogs renal ischemia-reperfusion resistive index Introduction Ischemic injury results when the blood recycle to a tissue is interrupted but paradoxically more severe tissue injury occurs when blood flow is restored on reperfusion 3 . Renal warm ischemia-reperfusion IZR injury occurs prior to removal of a kidney for transplantation and it is a major factor in resuscitation of the kidney. Unfortunately oxygen free radical OFR injury which occurs in oxygen metabolism can play an important role in the pathophysiology of the kidney ischemic-reperfusion injury 5 . When oxygen free radical is .
