Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Epitheliotropic cutaneous lymphoma (mycosis fungoides)in a dog | J. Vet. Sá. 2006 7 1 97-99 JOURNAL OF Case Report Veterinary Science Epitheliotropic cutaneous lymphoma mycosis fungoides in a dog Dong Ha Bhang1 U1 Soo Choi3 Min Kyu Kim1 Eun-Hwa Choi1 Min-Soo kang2 Cheol-Yong Hwang1 Dae-Yong Kim Hwa Young Youn Chang Woo Lee3 Departments of Veterinary Internal Medicine Veterinary Pathology and 3 Veterinary Clinical Pathology College of Veterinary Medicine. Seoul National University Seoul 151-742 Korea A seven-year-old castrated male Yorkshứe terrier dog was presented for a recurrent skin disease. Erythematous skin during the first visit progressed from multiple plaques to patch lesions and exudative erosion in the oral mucosa membrane. Biopsy samples were taken from erythematous skin and were diagnosed with epitheliotropic T cell cutaneous lymphoma by histopathology and immunochemical stain. In serum chemistry the dog had a hypercalcemia mg dl and mild increased alkaline phosphatase 417 u l . Immunohistochemistry was performed to detect parathyroid hormone-related peptide PTH-rP in epitheliotropic cutaneous lymphoma tissues but the neoplastic cells were not labeled with anti-PTH-rP antibodies. The patient was treated with prednisolone and isotretinoin. However the dog died unexpectedly. Key words dog. epitlieliotropic cutaneous lymphoma hypercalcemia. mycosis tungoides PTII-rP Malignant lymphoma accounts for 7-24 of all canine neoplasia 6 . Canine epitheliotropic T-cell lymphoma represents only 3-8 of all canine lymphomas . It can be subdivided into non-epitheliotropic and epitheliotropic forms 4 Epitheliotropic cutaneous lymphoma is usually of T cell origin and encompasses a spectrum of disease including mycosis fungides. Sezary syndrome and pagetoid reticulosis . It occurs in old dogs average age of 9 to 11 years and has no breed and sex predilection 1 Four clinical presentations of the disease have been described. Histopathologically. mycosis fiingoides is characterized mycosis cells 10 . The objective of this
