Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Excitability scores of goats administered ascorbic acid and transported during hot-dry conditions | J. Vet. Set. 2006 7 2 133-136 JOURNAL OF Veterinary Science Neuropharmacological effects of deltamethrin in rats s. Manna1 D. Bhattacharyya2 T. K. Mandal3 s. Dey4 institute of Animal Health and Veterinary Biologicals R T 37-Belgachia Rd Kolkata-700 037 India department ofPharmacology University College of Medicine Calcutta University 244-B A. J. c. Bose Rd Kolkata-20 India 3Department of Pharmacology and Toxicology West Bengal University of Animal and Fishery Sciences 68 K B. Sarani Kolkata-700 037 India Chittaranjan National Cancer Research Institute Kolkata India This study examined the effect of deltamethrin on some of the neuropharmacological paradigms in a rat brain such as the motor co-ordination test using a rotarod the pentobarbitone-induced sleeping time and pentylenetetrazole PTZ -induced convulsion as well as the gamma aminobutyric acid GABA level. Albino Wistar rats were used as the experimental animals. Different neuropharmacological paradigms such as the motor co-ordination by the rota rod pentobarbitone-induced sleeping time and the PTZ-induced convulsion were examined after administering deltamethrin orally at two doses 150 mg kg LDjo and 15 mg kg 1 10 ED50 . The GABA level in the rat brain was estimated by HPLC after a single oral dose of 150 mg kg deltamethrin. Deltamethrin significantly reduced the motor coordination decreased the onset time and increased the sleeping time duration induced by pentobarbitone. In addition it also decreased the onset time and increased the duration of convulsions induced by PTZ at 150 mg kg LDjo and 15mg kg 1 10 LDjo respectively. Further deltamethrin administration decreased the GABA levels in the cerebellum as well as in the whole brain except the cerebellum significantly at the LD50 dose level. There was some correlation between the effect of deltamethrin on the central GABA levels and its neuropharmacological effects. Key words convulsion deltamethrin GABA hypnosis rotarod test Introduction Deltamethrin s .
