Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunohistochemical localization of calcium binding proteins and some neurotransmitters in myenteric plexus of goat stomach | J. Vet. Set. 2006 7 4 315-319 JOURNAL OF Veterinary Science Immunohistochemical localization of calcium binding proteins and some neurotransmitters in myenteric plexus of goat stomach Heungshik s. Lee Young Sam Nam Department of Anatomy and Cell Biology College of Veterinary Medicine Seoul National University Seoul 151-742 Korea To understand the neurochemical properties of the gastric myenteric plexus of ruminants the expression patterns of calbindin D-28k CB calretinin CR substance p SP and calcitonin gene-related peptide CGRP were explored in the Korean native goat. In gastric myenteric plexus CB and SP immunoreactivity were observed in round- or ovalshaped neurons. CR and CGRP immunoreactivity were detected only in the nerve fibers. This immunohistochemical localization of CB CR CGRP and SP in the myenteric plexus of the goat stomach exhibited species-specific patterns. These findings suggest that these substances may be directly or indirectly related to the gastric functions of the goat stomach. Key words calbindin D-28k calcitonin gene-related peptide calretinin Korean native goat myenteric plexus substance p Introduction The enteric nervous system ENS is composed of the cell bodies and fibers that are localized between the muscle layers throughout the entfre gastrointestinal tract. The ENS integrates the motility secretion blood flow and immune response of the digestive tract independent of the extrinsic autonomic inputs 9 20 . The function of the ENS is to coordinate the complex interactions of the enteric networks which consist of sensory inter motor and secremotor neurons 2 6 9 . Based on localization the ENS is divided into the myenteric and submucosal plexus. The myenteric plexus is positioned between the outer longitudinal and inner cfrcular muscle layers throughout the digestive tract. Since the myenteric plexus modulates the contraction and relaxation of the smooth muscles 19 20 this plexus is an endogenous source for motor innervation to the .
