Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice | J. Vet. Sci. 2007 8 4 341-351 JOURNAL OF Veterinary Science Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice Amira M. K. Abouelella1 Yasser E. Shahein2 j Sameh S. Tawfik3 Ahmed M. Zahran1 Radiation Biology Department National Centre for Radiation Research and Technology NCRRT Cairo Egypt 2Molecular Biology Department National Research Centre Cairo Egypt 3Health Radiation Research Department National Centre for Radiation Research and Technology NCRRT Cairo Egypt Echinacea E. purpurea herb is commonly known as the purple coneflower red sunflower and rudbeckia. In this paper we report the curative efficacy of an Echinacea extract in Y-irradiated mice. E. purpurea was given to male mice that were divided into five groups control treated irradiated treated before irradiation treated after irradiation at a dose of 30 mg kg body weight for 2 weeks before and after irradiation with 3 Gy of Y-rays. The results reflected the detrimental reduction effects of Y-rays on peripheral blood hemoglobin and the levels of red blood cells differential white blood cells and bone marrow cells. The thiobarbituric acid-reactive substances TBARs level Superoxide dismutase SOD and glutathione peroxidase GSPx activities and DNA fragmentation were also investigated. FT-Raman spectroscopy was used to explore the structural changes in liver tissues. Significant changes were observed in the microenvironment of the major constituents including tyrosine and protein secondary structures. E. purpurea administration significantly ameliorated all estimated parameters. The radio-protection effectiveness was similar to the radio-recovery curativeness in comparison to the control group in most of the tested parameters. The radio-protection efficiency was greater than the radio-recovery in hemoglobin level during the first two weeks in lymphoid cell count and TBARs level at the fourth week and in SOD activity during the first two weeks as compared to the levels of these parameters in
