Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings | J. Vet. Sci. 2007 8 4 369-376 JOURNAL OF Veterinary Science Canine model of ischemic stroke with permanent middle cerebral artery occlusion clinical and histopathological findings r. rr . 1 t T . 2 t rx . T 1 . XX . 3 1 1 r o Byeong-Teck Kang Jong-Hwan Lee Dong-In Jung Chul Park Su-Hyun Gu Hyo-Won Jeon Dong-Pyo 5 1 2xz5 5 4 l_1 k Jang Chae-Young Lim Fu-Shi Quan Young-Bo Kim Zang-Hee Cho Eung-Je Woo Hee-Myung Park Department of Veterinary Internal Medicine and 2Department of Anatomy College of Veterinary Medicine Konkuk University Seoul 143-701 Korea 3Acupuncture Meridian Science Research Center and 4College of Electronics and Information Kyunghee University Yongin 446-701 Korea 5Neuroscience Research Institute Gachon University of Medicine and Science Incheon 405-760 Korea The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness head turning circling postural reaction deficits perceptual deficits and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex basal ganglia and thalamus were partially unstained with tri-phenyl-tetrazolium chloride. Histopathologically typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients. Key words dog histopathology ischemic stroke .
