Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats | J. Vet. Sci. 2008 9 1 25-29 JOURNAL OF Veterinary Science Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats Madhukar S. Dama1 C. Varshneya1 M. S. Dardi2 V. C. Katoch3 Department of Pharmacology and Toxicology College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University Palampur-176 062 Himachal Pradesh India 2Krishi Vigyan Kendra CSK HPAU Mandi at Sunder Nagar Distt Mandi Himachal Pradesh India 3Department of Veterinary Microbiology CSK Himachal Pradesh Agricultural University Palampur-176 062 Himachal Pradesh India The pharmacokinetics of orally administered pefloxacin were studied to evaluate the bio-enhancing effect of the herbal bio-enhancer trikatu in mountain Gaddi goats n 6 . The findings of the study revealed a decreased plasma concentration p of pefloxacin following trikatu administration during the absorption phase 10 15 20 min post pefloxacin administration . In contrast the plasma concentrations of pefloxacin were significantly higher at 4 6 8 and 12 h during the elimination phase of the pefloxacin administration. The findings of the investigation revealed higher values for the area under the curve the area under the first moment of the plasma drug concentration time curve the mean residential time the total duration of pharmacological action and bioavailability. Trikatu treatment however significantly reduced the elimination half life t1 2p and zero time intercept of the elimination phase. The apparent volume of distribution based on the total area under the plasma drug concentration curve Vd area and the apparent volume of distribution based on the zero time plasma concentration intercept of the elimination phase Vd B were significantly higher in trikatu treated animals indicating a better penetration of the drug. Based on the MIC of Mg ml of pefloxacin a priming dose of mg kg and a maintenance dose of mg kg is required to be administered at 8 h
