Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Efficacy of nano-hydroxyapatite prepared by an aqueous solution combustion technique in healing bone defects of goat | J. Vet. Sci. 2008 9 2 183-191 JOURNAL OF Veterinary Science Efficacy of nano-hydroxyapatite prepared by an aqueous solution combustion technique in healing bone defects of goat .1 2 2 1 2 Samit Kumar Nandi Biswanath Kundu Samir Kumar Ghosh Dipak Kumar De Debabrata Basu Department of Veterinary Surgery and Radiology West Bengal University of Animal and Fishery Sciences Kolkata India 2Bioceramics and Coating Division Central Glass and Ceramic Research Institute Kolkata India The present study was undertaken to evaluate porous hydroxyapatite HAp the powder of which was prepared by a novel aqueous solution combustion technique as a bone substitute in healing bone defects in vivo as assessed by radiologic and histopathologic methods oxytetracycline labeling and angiogenic features in Bengal goat. Bone defects were created in the diaphysis of the radius and either not filled group I or filled with a HAp strut group II . The radiologic study in group II showed the presence of unabsorbed implants which acted as a scaffold for new bone growth across the defect and the quality of healing of the bone defect was almost indistinguishable from the control group in which the defect was more or less similar although the newly formed bony tissue was more organized when HAp was used. Histologic methods showed complete normal ossification with development of Haversian canals and well-defined osteoblasts at the periphery in group II whereas the control group had moderate fibro-collagenization and an adequate amount of marrow material fat cells and blood vessels. An oxytetracycline labeling study showed moderate activity of new bone formation with crossing-over of new bone trabeculae along with the presence of resorption cavities in group II whereas in the control group the process of new bone formation was active from both ends and the defect site appeared as a homogenous non-fluoroscent area. Angiograms of the animals in the control group showed uniform angiogenesis in the defect .
