Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration | J. Vet. Sci. 2008 9 3 241-245 JOURNAL OF Veterinary Science Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration Pi -nụp . vaiiia S. Tia vez .J. I miova N. K. r aii Laj r. K. vei Ha Division of Pharmacology and Toxicology Faculty of Veterinary Sciences and Animal Husbandry She-e-Kasmir University of Agricultural Sciences and Technology of Jammu Jammu 181102 India 2Department of Pharmacology Toxicology and Therapeutics Faculty of Veterinary Medicine Trakia University Stara Zagora Bulgaria We evaluated the pharmacokinetics of ciprofloxacin in serum n 6 and urine n 4 in goats following a single intravenous administration of 4 mg kg body weight. The serum concentration-time curves of ciprofloxacin were best fitted by a two-compartment open model. The drug was detected in goat serum up to 12 h. The elimination rate constant P and elimination half-life t1 2P were h-1 and h respectively. The apparent volume of distribution at steady state Vdss was l kg and the total body clearance C1b was ml min kg. Urinary recovery of ciprofloxacin was of the administered dose within 36 h post administration. In vitro serum protein binding was 41 . Thus a single daily intravenous dose of 4 mg kg is sufficient to maintain effective levels in serum and for 36 h in urine allowing treatment of systemic Gram-negative bacterial infections and urinary tract infections by most pathogens. Keywords ciprofloxacin disposition kinetics goat urinary excretion Introduction Ciprofloxacin is a fluoroquinolone derivative in veterinary medicine with outstanding antibacterial activity primarily against Gram-negative pathogens but also Gram-positive bacteria and some Chlamydia Mycoplasma and many Mycobacterium species 12 23 24 . The pharmacokinetics of ciprofloxacin has been investigated in dogs rats and monkeys rabbits ponies goats cow calves and buffalo calves 4 8 29 30 33 34 37 . .
