Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice | J. Vet. Sci. 2009 10 3 189-195 DOI JOURNAL OF Veterinary Science Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL 6J ob ob mice 1 1 2 3 4 4 Jin-Joo Hue Ki Nam Lee Jae-Hwang Jeong Sang-Hwa Lee Young Ho Lee Seong-woon Jeong Sang Yoon Nam1 Young Won Yun1 Beom Jun Lee1 College of Veterinary Medicine and Research Institute of Veterinary Medicine Chungbuk National University Cheongju 361-763 Korea 2Department of Biotechnology and Biomedicine Chungbuk Province College Okcheon 373-807 Korea 3Department of Food and Nutrition Seowon University Cheongju 361-742 Korea 4Ilshinwells Cheongwon 363-890 Korea This study was to investigate the anti-obesity effects of diglyceride DG -conjugated linoleic acid CLA containing 22 CLA as fatty acids in C57BL 6J ob ob male mice. There were four experimental groups including vehicle control DG CLA and DG-CLA. The test solutions of 750 mg kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control p . All test solutions significantly decreased the levels of triglyceride glucose and free fatty acids in the serum compared with control p . The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group p . CLA significantly decreased weights of renal and epididymal fats compared with the control p . DG and DG-CLA also significantly decreased the epididymal fat weights compared with the control p . A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG CLA and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22 CLA have a respectable anti-obesity effect by controlling .
