Thuyết di truyền có lẽ là thuyết khoa học nhất. Theo thuyết này thì con người có sẵn trong các tế bào của mình một chương trình – mang trong các “gen”. Các gen hoạt động theo thứ tự, bất di bất dịch: sinh, lão, bệnh, tử. | 468 NOVEL CELLULAR PATHWAYS REFERENCES Arrasate M Mitra S Schweitzer ES Segal MR Finkbeiner S. 2004. Inclusion body formation reduces levels of mutant huntington and the risk of neuronal death. Nature. 431 805-810. AutereJ MoilanenJS Finnila S Soininen H et al. 2004. Mitochondrial DNA polymorphisms as risk factors for Parkinson s disease and Parkinson s disease dementia. Hum Genet. 115 29-35. Balakirev MY Khramtsov VV Zimmer G. 1997. Modulation of the mitochondrial permeability transition by nitric oxide. Eur JBiochem. 246 710-718. Baran H Jellinger K Deecke L. 1999. Kynurenine metabolism in Alzheimer s disease. J Neural Transm. 106 165-181. Beal MF. 1992. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenera-tive illnesses Ann Neurology. 31 119-130. Beal MF. 1997. Oxidative damage in neurodegenerative diseases. Neuroscientist. 3 21-27. Beal MF. 2000. Energetics in the pathogenesis of neurode-generative diseases. Trends Neurosci. 23 298-304. Beal MF Kowall NW Ellison DW Mazurek MF Swartz KJ Martin JB. 1986. Replication of the neurochemical characteristics of Huntington s disease by quinolinic acid. Nature. 321 168-171. Beal MF Ferrante RJ Swartz KJ Kowall NW. 1991. Chronic quinolinic acid lesions in rats closely resemble Huntington s disease. J Neurosci. 11 1649-1659. Beal MF Matson WR Storey E et al. 1992. Kynurenic acid concentrations are reduced in Huntington s disease cerebral cortex. J Neurol Sci. 108 80-87. Beal MF Brouillet E Jenkins BG et al. 1993. Neurochemical and histologic characterization of striatal exci-totoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci. 13 4181-4192. Beckman JS Beckman TW Chen J Marshall PA Freeman BA. 1990. Apparent hydroxyl radical production by peroxynitrite implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 87 1620-1624. Bence NF Sampat RM Kopito RR. 2001. Impairment of the ubiquitin-proteasome system by protein .
