Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model. | Int. J. Med. Sci. 2007 4 203 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 4 203-208 Ivyspring International Publisher. All rights reserved In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model Satoshi Ishizone 1 Fukuto Maruta 1 Kazufumi Suzuki 1 Shinichi Miyagawa 1 Masahiko Takeuchi 2 Kiyomi Kanaya 3 Kozue Oana 4 Masayoshi Hayama 4 Yoshiyuki Kawakami 4 Hiroyoshi Ota 4 1. Department of Surgery Shinshu University School of Medicine Matsumoto Japan 2. Agricultural Technology Institute Nagano Farmer s Federation Japan 3. Nagano Kohno Co. Ltd. Japan 4. Department of Biomedical Laboratory Sciences School of Health Sciences Shinshu University School of Medicine Japan Correspondence to Dr. Satoshi Ishizone Department of Surgery Shinshu University School of Medicine Asahi 3-1-1 Matsumoto 390-8621 Japan. E-mail ishizone@ Received Accepted Published Purpose The antibiotic effect of rice-fluid on Helicobacter pylori infection was investigated using a Mongolian gerbil model. Methods Gerbils were divided into four groups H. pylori -infected rice-fluid-treated animals group A H. pylori -infected untreated animals group B uninfected rice-fluid-treated animals group C and uninfected untreated animals group D . Group A and B animals were killed 14 weeks after H. pylori infection and group C and D animals were killed at the same age. The stomachs were examined for histology 5 -bromo-2 -deoxyuridine BrdU labeling and the bacterial burden. Serum anti-H. pylori antibody titers were also tested. Results The positive incidence of H. pylori -culture was 25 and 84 in groups A and B respectively p . Both the degree of inflammation and the BrdU labeling index in group A were significantly lower than those in group B. Conclusions Rice-fluid showed an antibiotic effect on H. pylori and an anti-inflammatory effect on the H. pylori -associated
