Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma. | Int. J. Med. Sci. 2007 4 264 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 5 264-266 Ivyspring International Publisher. All rights reserved Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma Keisuke Nakano1 2 Takehiro Watanabe1 Takako Shimizu2 and Toshiyuki Kawakami 1 2 1. Hard Tissue Pathology Unit Matsumoto Dental University Graduate School of Oral Medicine Shiojiri Japan 2. Hard Tissue Pathology Unit Matsumoto Dental University Institute for Oral Science Shiojiri Japan Correspondence to Keisuke Nakano DDS PhD Assistant Professor Hard Tissue Pathology Unit Department of Hard Tissue Research Matsumoto Dental University Graduate School of Oral Medicine 1780 Hirooka-Gobara Shiojiri 399-0781 Japan. Tel 81- 0 263-51-2035 Fax 81- 0 263-51-2035 E-mail keisuke1@ Received Accepted Published Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore positive reaction was detected in the bone forming cells osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells. Key words Bone forming cells Immunohistochemical characteristics Pleomorphic adenoma Modified myoepithelial cell Trans-differentiation 1. Introduction Pleomorphic adenomas can display a variety of histopathological features such as myxomatous changes cartilage and bone formation in so-called stromal tissue of the neoplasms. According to the World
