Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema. | Int. J. Med. Sci. 2008 5 18 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2008 5 1 18-23 Ivyspring International Publisher. All rights reserved Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema Pedro J Modrego1 Beatriz Boned2 Juan J Berlanga3 Mercedes Serrano3 1. Dept of Neurology. Miguel Servet University Hospital. Zaragoza. Spain 2. Biochemistry Unit. Hospital de Alcaniz. Spain 3. Neurology Unit. Hospital de Alcaniz. Spain Correspondence to Dr PJ Modrego Dept of Neurology Miguel Servet University Hospital 50009 Zaragoza Spain. E-mail med009626@ Received Accepted Published OBJECTIVE. Plasmatic B-type-natriuretic peptide NT-PBNP and C-reactive protein CRP have been reportedly eleVated in stroke patients however their clinical significance remains uncertain. The purpose of this work is to investigate whether elevation of these proteins at baseline predicts CT-evidence of brain edema. METHODS. We recruited 41 consecutive patients with stroke and determined NT-PBNP and CRP at baseline within 5 hours after onset after 48-72 hours and at discharge. Stroke severity was measured by means of the NIHS scale at baseline and at discharge. We also carried out brain CT at admittance and after 48 hours. RESULTS. There were 29 ischemic strokes and 12 hemorrhagic strokes. Evidence of brain edema on delayed scan was seen in 14 patients. Baseline levels of NT-PBNP did not predict CT-evidence of edema but CRP levels did so significantly mg dl in patients without edema versus mg in patients with edema p . Both NT-PBNP and PC levels correlated poorly to NIHSS score and increased markedly from baseline to the second determination in patients with edema. For these patients the NT-PBNP increase was pmol l in comparison to pmol l in patients without edema p . Neither CRP nor NT-PBNP baseline levels were
