Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy. | Int. J. Med. Sci. 2008 5 62 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2008 5 2 62-67 Ivyspring International Publisher. All rights reserved A 12 Week Open Label Phase I IIa Study Using Apatone for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy Basir Tareen1 Jack L. Summers1 James M. Jamison1 Deborah R. Neal1 Karen McGuire1 Lowell Gerson1 and Ananias Diokno 2 1. Summa Health System Department of Urology Akron Ohio USA 2. William Beaumont Hospital Department of Urology Royal Oak Michigan USA Correspondence to Basir Tareen . Department of Urology New York University 550 First Avenue New York NY 10016. tareen@ Received Accepted Published Purpose To evaluate the safety and efficacy of oral Apatone Vitamin C and Vitamin K3 administration in the treatment of prostate cancer in patients who failed standard therapy. Materials and Methods Seventeen patients with 2 successive rises in PSA after failure of standard local therapy were treated with 5 000 mg of VC and 50 mg of VK3 each day for a period of 12 weeks. Prostate Specific Antigen PSA levels PSA velocity PSAV and PSA doubling times PSADT were calculated before and during treatment at 6 week intervals. Following the initial 12 week trial 15 of 17 patients opted to continue treatment for an additional period ranging from 6 to 24 months. PSA values were followed for these patients. Results At the conclusion of the 12 week treatment period PSAV decreased and PSADT increased in 13 of 17 patients p . There were no dose-limiting adverse effects. Of the 15 patients who continued on Apatone after 12 weeks only 1 death occurred after 14 months of treatment. Conclusion Apatone showed promise in delaying biochemical progression in this group of end stage prostate cancer patients. Key words Prostate Prostate neoplasms ascorbic acid menadione Vitamin K3 Apatone Cancer Introduction The PSA era has led to
