Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Expression and function of micro RNAs in immune cells during normal or disease state. | Int. J. Med. Sci. 2008 5 73 International Journal of Medical Sciences ISSN 1449-1907 2008 5 2 73-79 Ivyspring International Publisher. All rights reserved Review Expression and function of micro RNAs in immune cells during normal or disease state Esmerina Tili 1 Jean-Jacques Michaille 1 2 and George Adrian Calin 3 1. Ohio State University Department of Molecular Virology Immunology and Medical Genetics and Comprehensive Cancer Center 385L Wiseman Hall 400 W. 12th Ave. Columbus OH 43210. 2. INSERM U866 Université de Bourgogne Dijon France. 3. Department of Experimental Therapeutics and Department of Cancer Genetics University of Texas MD Anderson Cancer Center Houston TX 77030. Correspondence to Dr. George A. Calin Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston TX 77030. Tel 1 713 792 5461 e-mail gcalin@ Received Accepted Published Micro RNAs miRNAs are 19-24 nucleotide long non-coding RNAs that posttranscriptionally modulate gene expression. They are found in almost all species viruses plants nematodes fly fish mouse human and are implicated in a wide array of cellular and developmental processes. Microarray-based miRNA profiling brought to the discovery of miRNAs specific to different hematopoietic lineages. Furthermore the functional assays performed in tissue cultures to discover miRNAs involved in immune responses in combination with the reports of miRNA-transgenic or miRNA-knockout mouse models has helped elucidating the miRNA roles in the development and function of immune system. Abnormal patterns of hematopoietic-specific miRNAs have been found in different types of cancer and miRNA based gene therapy is being considered as a potential technology of choice in immunological disorders and cancer. The purpose of this review is to discuss recent findings related with the expression and function of miRNAs in hematopoietic lineages. Key words Acquired .
