Int. J. Med. Sci. 2008, 5 327 International Journal of Medical Sciences Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Efficacy of Radiofrequency Ablation of Hepatocellular Carcinoma Associated with Chronic Liver Disease without Cirrhosis. | Int. J. Med. Sci. 2008 5 327 Short Research Communication International Journal of Medical Sciences ISSN 1449-1907 2008 5 6 327-332 Ivyspring International Publisher. All rights reserved Efficacy of Radiofrequency Ablation of Hepatocellular Carcinoma Associated with Chronic Liver Disease without Cirrhosis Andrea Salmi1 H Renato Turrini1 Giovanna Lanzani1 Antonella Savio2 Livio Anglani3 1. Gastroenterology Unit AFAR Ospedale Fatebenefratelli Brescia Italy. 2. Pathology Department Ospedale Fatebenefratelli Brescia Italy. 3. IRCCS Statistical department San Giovanni di Dio Fatebenefratelli Brescia. H Correspondence to Andrea Salmi MD asalmi@ Received Accepted Published Background. Hepatocellular carcinoma is one of the leading causes of death for compensated chronic liver disease. Aim. The evaluation of technical success as primary ablation rate local tumor progression safety and long-term patients outcome of radiofrequency ablation in single less than cm in diameter or multiple nodules up to 3 sized less than 3 cm of hepatocellular carcinoma associated to chronic liver disease without cirrhosis. Materials and Methods. 25 consecutive patients mainly chronic hepatitis C with surgical unresectable hepatocellular carcinoma due to comorbidity or tumor location recruited from a local sonographic screening were treated. Results. Primary ablation was obtained in 96 of patients 24 out of 25 and in 93 of nodules 27 out of 29 . 1 3 and 5-year local tumor progression rates after treatment were 4 14 and 14 . Survival rates at 1 3 and 5-year were 92 72 and 64 . No treatment-related deaths and severe complications were recorded. Conclusions. Radiofrequency ablation is effective with 96 of primary ablation with few tumoral recurrence and limited morbidity in patients with hepatocellular carcinoma associated with chronic liver disease without cirrhosis it could represent a valid alternative .
