Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients. | Int. J. Med. Sci. 2008 5 371 International Journal of Medical Sciences ISSN 1449-1907 2008 5 6 371-376 Ivyspring International Publisher. All rights reserved Research Paper Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients Hans-Peter Hauber1 2 H Maria Schulz2 Almuth Pforte2 Dietrich Mack3 Peter Zabel1 Udo Schumacher4 1. Medical Clinic Research Center Borstel Department of Medicine Borstel Germany. 2. Department of Medicine I University Hospital Hamburg-Eppendorf Germany. 3. Department of Microbiology and Immunology University Hospital Hamburg-Eppendorf Germany. 4. Department of Anatomy II Experimental Morphology University Hospital Hamburg-Eppendorf Germany H Correspondence to Priv. Doz. Dr. med. Hans-Peter Hauber Research Center Borstel Department of Medicine Parkallee 35 23845 Borstel Germany. Tel 49-4537-188-0 Fax 49-4537-188-313 E-mail hphauber@ Received Accepted Published Background Colonisation of cystic fibrosis CF lungs with Pseudomonas aeruginosa is facilitated by two lectins which bind to the sugar coat of the surface lining epithelia and stop the cilia beating. Objectives We hypothesized that P. aeruginosa lung infection should be cleared by inhalation of fucose and galactose which compete for the sugar binding site of the two lectins and thus inhibit the binding of P. aeruginosa. Methods 11 adult CF patients with chronic infection with P. aeruginosa were treated twice daily with inhalation of a fucose galactose solution for 21 days 4 patients only received inhalation 7 patients received inhalation and intravenous antibiotics . Microbial counts of P. aeruginosa lung function measurements and inflammatory markers were determined before and after treatment. Results The sugar inhalation was well tolerated and no adverse side effects were observed. Inhalation alone as well as combined therapy inhalation and antibiotics significantly decreased .
