Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus. | Int. J. Med. Sci. 2004 1 3 146-151 146 International Journal of Medical Sciences Research paper ISSN 1449-1907 2004 1 3 146-151 2004 Ivyspring International Publisher. All rights reserved Expression of hMSH2 protein of the human DNA mismatch Received Accepted Published repair system in oral lichen planus Flavio Juliano Garcia Santos Pimenta1 Maria das Graẹas Rodrigues Pinheiro2 Ricardo Santiago Gomez1 1 Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil. 2 School of Dentistry Centro de Ensino Superior do Pará Belém Brazil. Abstract Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA mismatch repair hMMR genes and it plays an important role in reducing mutation and maintaining genomic stability. hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma. In this study we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium. We examined the expression of hMSH2 protein by immunohistochemistry in twenty-six cases of oral lichen planus. Clinically 12 of them were categorized into reticular subtype and 14 were atrophic erosive. Ten cases of normal mucosa were added to the control group. Results showed that the percentage of positive cells to hMSH2 was smaller in reticular p 0 006 and atrophic erosive p 0 028 subtypes of oral lichen planus compared to normal mucosa . The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more .
