Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Advances in Molecular Diagnosis of HBV Infection and Drug Resistance. | Int. J. Med. Sci. 2005 2 1 8 International Journal of Medical Sciences ISSN 1449-1907 2005 2 1 8-16 2005 Ivyspring International Publisher. All rights reserved Review Received Accepted Published Advances in Molecular Diagnosis of HBV Infection and Drug Resistance Erwin Sablon and Fred Shapiro Innogenetics NV Industriepark Zwijnaarde Belgium Abstract Serological markers are key elements in diagnosing acute hepatitis B virus HBV infection and determining its possible evolution towards chronicity. Once treatment of chronic HBV is initiated with approved anti-hepadnaviral agents such as lamivudine interferon-alpha or adefovir dipivoxil the measurement of HBV DNA in serum can not only help monitor treatment efficacy but also indicates breakthrough infection should drug resistance emerge. Advances in the molecular diagnosis of drug resistance using highly sensitive methodologies such as DNA hybridization assays can further pinpoint the type of mutation responsible and more importantly detect upcoming viral resistance at an early stage when the variant represents only a minor fraction of the total viral population. Such new tools are especially relevant for patients at high risk for disease progression or acute exacerbation. Recent diagnostic developments including HBV genotyping and precore core promoter assays that could well play important future roles in hBv patient management are also reviewed. Key words Molecular Diagnosis HBV Infection Drug Resistance Author biography Erwin Sablon PhD is currently the Head of the Hepatology Unit in the Diagnostics R D Division at Innogenetics. His key interests include the molecular basis of drug resistance and genetic variability of the hepatitis B and C viruses as well as serum markers for liver fibrosis. Fred Shapiro MLS is the Head of the Medical Writing Science Editing and Science Information Departments at Innogenetics. His principle research interests include diagnosis and .
