Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations. | Int. J. Med. Sci. 2005 2 58 International Journal of Medical Sciences Research paper ISSN 1449-1907 2005 2 2 58-63 2005 Ivyspring International Publisher. All rights reserved A folate-rich diet is as effective as folic acid from supplements Received Accepted Published in decreasing plasma homocysteine concentrations Xavier Pintó 1 M. Antonia Vilaseca 2 Susana Balcells 3 Rafael Artuch 2 Emili Corbella 1 José F. Meco 1 Ramon Vila 4 Ramon Pujol 1 Daniel Grinberg 3 1. Unitat de Lípids i Arteriosclerosi Servei de Medicina Interna Hospital Universitari de Bellvitge IDIBELL c Feixa Llarga s n 08907 Hospitalet de Llobregat Barcelona Spain. 2. Unitat de Metabolopaties. Servei de Bioquimica. Hospital de Sant Joan de Déu. Passeig Sant Joan de Déu 2 08950 Esplugues de Llobregat. Barcelona. Spain. 3. Departament de Genètica. Facultat de Biologia. Universitat de Barcelona. Avda. Diagonal 645 08028 Barcelona. Spain. 4. Servei d Angiologia i Cirurgia Vascular. Hospital Universitari de Bellvitge IDIBELL c Feixa Llarga s n 08907 Hospitalet de Llobregat Barcelona Spain Abstract Background Aims At least 500 pg of folic acid are required daily to treat hyperhomocysteinemia. To reach this amount by dietary changes alone may be difficult because food has a low folic acid content and bioavailability. No studies have compared the effects of similar amounts of additional folate derived from a combination of folate-rich and fortified foods or folic acid from supplements on plasma total homocysteine tHcy concentrations which was the aim of this study. Methods Twenty male patients with hyperhomocysteinemia and coronary artery disease were included in a randomized crossover intervention trial. Patients were treated daily with a combination of foods containing approximately 500 pg of folate or with one 500 pg capsule of synthetic folic acid over two five-week periods separated by a five-week wash-out period. Results Plasma folate increased markedly
