Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Differential gene expression in HIV/SIV-associated and spontaneous lymphomas. | Int. J. Med. Sci. 2005 2 122 Research paper International Journal of Medical Sciences ISSN 1449-1907 2005 2 4 122-128 2005 Ivyspring International Publisher. All rights reserved Differential gene expression in HIV SIV-associated and spontaneous lymphomas Nenasheva 1 Nikolaev 1 AV Martynenko 1 Kaplanskaya 2 W Bodemer 3 G Hunsmann 4 Tarantul 1 1. Institute of Molecular Genetics Russian Academy of Sciences Kurchatov sq. 2 Moscow Russia 2. National Research Center of Hematology Russian Academy of Medical Sciences Novozykovskii pr. 4a Moscow Russia 3. Department of Infection Pathology GermanPrimate Center Kelnerweg 4 Goettingen Germany 4. Department of Virology and Immunology German Primate Center Kelnerweg 4 Goettingen Germany Corresponding address Prof. . Tarantul Deputy Director Institute of Molecular Genetics RAS Kurchatov Sq. 2 Moscow 123182 Russia. Phone Fax 7-095-196-00-02 Fax 7-095-196-02-21 tarantul@ Received Accepted Published Diffuse large B-cell lymphoma DLBCL is more prevalent and more often fatal in HIV-infected patients and SIV-infected monkeys compared to immune-competent Individuals. Molecular biological and immunological data indicate that virus-associated lymphomagenesis is similar in both infected hosts. To find genes specifically overexpressed in HIV SIV-associated and non-HIV SIV-associated DLBCL we compared gene expression profiles of HIV SIV-related and non-HIV-related lymphomas using subtractive hybridization and Northern blot analysis. Our experimental approach allowed us to detect two genes a-myb and pub upregulated solely in HIV SIV-associated DLBCLs potentially involved in virus-specific lymphomagenesis in human and monkey. Downregulation of the pub gene was observed in all non-HIV-associated lymphomas investigated. In addition we have found genes upregulated in both non-HIV- and HIV-associated lymphomast Among those were genes both with known set ND4 SMG-i and .
