Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Molecular Virology of Hepatitis C Virus (HCV): 2006 Update. | Int. J. Med. Sci. 2006 3 29 International Journal of Medical Sciences ISSN 1449-1907 2006 3 2 29-34 2006 Ivyspring International Publisher. All rights reserved Review Molecular Virology of Hepatitis C Virus HCV 2006 Update Volker Brass 1 Darius Moradpour2 and Hubert E. Blum1 1. Department of Medicine II University of Freiburg D-79106 Freiburg Germany 2. Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois University of Lausanne CH-1011 Lausanne Switzerland Corresponding address Hubert E. Blum . Department of Medicine II University of Freiburg Hugstetter Strasse 55 D-79106 Freiburg Germany. Tel. 49 761 270 3403. Fax 49 761 270 3610. E-mail Received Accepted Published Fascinating progress in the understanding of the molecular biology of hepatitis C virus HCV was achieved recently. The replicon system revolutionized the investigation of HCV RNA replication and facilitated drug discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mechanisms. Most recently recombinant infectious HCV could be produced in cell culture rendering all steps of the viral life cycle including entry and release of viral particles amenable to systematic analysis. In this review we summarize recent advances and discuss future research directions. Key words helicase hepatitis C virus protease polymerase replicon 1. Introduction The hepatitis C virus HCV belongs to the Flaviviridae family and is the only member of the Hepacivirus genus. HCV infection is a major cause of chronic hepatitis liver cirrhosis and hepatocellular carcinoma HCC worldwide 1 . Therapeutic options are improving but are still limited and a protective vaccine is not available to date. In 50 to 80 acute HCV infection persists and 4 to 20 of patients with chronic hepatitis C will develop liver cirrhosis within
