Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women. | Int. J. Med. Sci. 2006 3 108 Research paper International Journal of Medical Sciences ISSN 1449-1907 2006 3 3 108-111 2006 Ivyspring International Publisher. All rights reserved Association of the T 294C polymorphism in PPAR Ỗ with low HDL cholesterol and coronary heart disease risk in women Jens Aberle Inga Hopfer Frank Ulrich Beil Udo Seedorf Zentrum fur Innere Medizin Universitatsklinikum Hamburg-Eppendorf Martinistr. 52 20246 Hamburg Germany Corresponding address Jens Aberle e-mail aberle@ Tel. 0049 40 42803 4449 Fax 0049 40 42803 8290 Received Accepted Published Background The T294C polymorphism in PPARÔ represents a functional SNP affecting transcriptional activity of the PPARS gene. To address whether this polymorphism is associated with the risk for coronary heart disease and or plasma lipid levels in women we studied a group of 967 female patients with hyperlipidaemia in the presence n 453 or absence n 514 of coronary heart disease Methods 967 female patients with or without coronary heart disease were genotyped using mutagenically separated polymerase chain reaction MS-PCR . Statistical analysis was performed according to genotype with parameters of lipid metabolism as dependant variables. Results A highly significant association between the rare C allele and lower plasma HDL concentrations was found in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a bMi below the median. Moreover a significant association of the C-allele with coronary heart disease and BMI was obtained. Regarding the entire group trends towards higher VLDL and LDL levels were observed. Conclusions Our data show for the first time that the PPARÔ T294C polymorphism is associated with lipid levels and coronary heart disease in women. However the molecular mechanism of action remains to be elucidated. 1. Background .
