Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: In vitro bactericidal activities of Japanese rice-fluid against Helicobacter pylori strains. | Int. J. Med. Sci. 2006 3 112 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2006 3 3 112-116 2006 Ivyspring International Publisher. All rights reserved In vitro bactericidal activities of Japanese rice-fluid against Helicobacter pylori strains Yoshiyuki Kawakami1 Kozue Oana1 Masayoshi Hayama1 Hiroyoshi Ota1 Masahiko Takeuchi2 Kazuhiro Miyashita2 Tsunetomo Matsuzawa2 and Kiyomi Kanaya3 1. Department of Biomedical Laboratory Sciences School of Health Sciences Shinshu University School of Medicine Matsumoto 390-8621 Japan 2. Agricultural Technology Institute Nagano Farmers Federation Suzaka 382-0084 Japan 3. Nagano Kohno Co. Ltd. 3 Nagano 380-0948 Japan Correspondence to Professor Yoshiyuki Kawakami PhD Tel 81-026-337-2381 Fax 81-026-337-2370 E-mail yk23724@ Received Accepted Published Background Helicobacter pylori has now been widely recognized as a causative agent of gastroduodenal diseases. The development of safer anti- H. pylori compounds is desirable due to the antibiotic-resistant strains emerged to date. Methods We successfully developed the compounds of Rice-fluid derived from unpolished polished and usually cooked Japanese rice and investigated their in vitro antibacterial activities by means of the Time-Kill-Curve methods against various species of bacteria including H. pylori strains. Results All of the compounds revealed keen bactericidal activities against H. pylori followed by Streptococcus pneumoniae and Campylobacter jejuni strains but failed to affect the viability of other bacterial species investigated including staphylococci enterococci Pseudomonas aeruginosa and other gram-negative rods belonging to the family Enterobacteraceae. The bactericidal activities were demonstrated to be time- and concentration-dependent. Conclusions The compounds of Rice-fluid are considered to be potentially new and safe therapeutic regimens against H. pylori infections. The
