Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. | Int. J. Med. Sci. 2007 4 1 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 1 1-6 Ivyspring International Publisher. All rights reserved Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy Yasuyuki Goto 1 Takafumi Ando 2 Kazuko Nishio 1 Sayo Kawai 1 Yoshiko Ishida 1 Mariko Naito 1 Hidemi Goto 2 Nobuyuki Hamajima 1 1. Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan 2. Department of Gastroenterology Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan Correspondence to Yasuyuki Goto . . Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan. Tel 81-52-744-2133 Fax 81-52-744-2971 e-mail y-goto@ Received Accepted Published Background Various single nucleotide polymorphisms SNPs have explained the association between Helicobacter pylori H. pylori and gastric atrophy and cancer. This study investigated the associations of Grb2 associated binder 1 Gab 1 polymorphism and the combination of PTPN11 gene encoding src homology 2 domain-containing protein tyrosine phosphatase-2 SHP2 and Gab1 gene with gastric cancer and gastric atrophy among H. pylori seropositive subjects. Methods A single nucleotide polymorphism at intron 2 of Gab1 JST164345 was examined for 454 Japanese health checkup examinees 126 males and 328 females aged 35 to 85 without a history of gastric cancer and 202 gastric cancer patients 134 males and 68 females aged 33 to 94 with pathologically confirmed diagnosis of gastric adenocarcinoma. Results The decreased OR of the Gabi A A for H. pylori seropositivity was 95 confidence interval CI . Among seropositive healthy controls the OR of the Gabi G A A A for .
