Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: HIV DNA and Dementia in Treatment-Naïve HIV-1-Infected Individuals in Bangkok, Thailand. | Int. J. Med. Sci. 2007 4 13 Short Research Communication International Journal of Medical Sciences ISSN 1449-1907 2007 4 1 13-18 Ivyspring International Publisher. All rights reserved HIV DNA and Dementia in Treatment-Naive HIV-1-Infected Individuals in Bangkok Thailand Bruce Shiramizu1 Silvia Ratto-Kim1 2 Pasiri Sithinamsuwan3 Samart Nidhinandana3 Sataporn Thitivi-chianlert3 George Watt1 Mark deSouza2 Thippawan Chuenchitra2 Suchitra Sukwit2 Suwicha Chitpatima4 Kevin Robertson5 Robert Paul6 Cecilia Shikuma1 Victor Valcour1 1. Hawaii AIDS Clinical Research Program University of Hawaii Honolulu HI USA 2. Armed Forces Research Inst. Med. Sciences Bangkok Thailand 3. Phramongkutklao Hosp. Bangkok Thailand 4. Royal Thai Army Med. Dept. Bangkok Thailand 5. Univ. North Carolina Chapel Hill NC USA 6. Univ. Missouri Dept. Psychology St. Louis MO USA - for the South East Asia Research Collaboration with the Univ. of Hawaii Protocol 001 Team. Correspondence to B. Shiramizu MD 3675 Kilauea Ave. Young Bldg. 5th Floor Honolulu Hawaii USA 96816 Phone 808-737-2751 Fax 808-735-7047 bshirami@hawaii. edu Received Accepted Published High HIV-1 DNA HIV DNA levels in peripheral blood mononuclear cells PBMC correlate with HIV-1-associated dementia HAD in patients on highly active antiretroviral therapy HAART . If this relationship also exists among HAART-naive patients then HIV DNA may be implicated in the pathogenesis of HAD. In this study we evaluated the relationship between HIV DNA and cognition in subjects naive to HAART in a neuroAIDS cohort in Bangkok Thailand. Subjects with and without hAd were recruited and matched for age gender education and cD4 cell count. PBMC and cellular subsets were analyzed for HIV DNA using real-time PcR. The median logic HIV DNA copies per 106 PBMC for subjects with Had n 15 was which was higher than that found in subjects without dementia ND n 15 p . This finding was unchanged in a .
