Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease. | Int. J. Med. Sci. 2007 4 124 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 3 124-130 Ivyspring International Publisher. All rights reserved Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease Jagdish Gondalia 1 Bjorn Fagerberg 2 Johannes Hulthe 2 Lars Karlstrom 3 Ulf Nilsson 4 Susanna Waters5 and Olof Jonsson1 1. Department of Urology Sahlgrenska University Hospital Goteborg Sweden 2. Wallenberg Laboratory for Cardiovascular Research Sahlgrenska University Hospital Goteborg Sweden 3. Department of Vascular Surgery Sahlgrenska University Hospital Goteborg Sweden 4. The Renal Center Department of Nephrology Sahlgrenska University Hospital Goteborg Sweden 5. Department of Carlsson Research . 444 Goteborg Sweden Correspondence to Prof. Olof Jonsson Tel 46 31 3421000 fax 46 31 821740 E-mail Received Accepted Published Background Free radical production is elevated in jugular venous blood emerging from the brain in conjunction with carotid endarterectomy. This study explores the relationships betweenmarkers for lesion progression in arteriosclerosis production of radicals and clinical characteristics. Methods The radical production during carotid endarterectomy was studied in 13 patients with an ex vivo spin trap method using OXANOH as a spin trap. MCP-1 ICAM-1 MMP-9 and oxLDL were determined in venous blood samples before during and after clamping of the carotid artery. Principal component analysis PCA as well as partial least square regression analysis pLS was applied to interpret the data. Results PCA and PLS analysis revealed that high values of MMP-9 and low values of ICAM-1 were associated with high radical production whereas MCP-1 and oxLDL were not correlated to radical production. MMP-9 was elevated at diabetes high haemoglobin high leucocyte counts and thrombocyte counts as well as at .
