Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes. | Int. J. Med. Sci. 2010 7 I International Journal of Medical Sciences 2010 7 1 1-14 Ivyspring International Publisher. All rights reserved Research Paper Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes Valeria de Mello Coelho1 4 Allyson Bunbury1 Leticia B. Rangel2 Banabihari Giri1 Ashani Weeraratna1 Patrice J. Morin 2 Michel Bernier3 and Dennis D. Taub1 M 1. Laboratories of Immunology National Institute on Aging National Institutes of Health Baltimore MD USA 2. Cellular and Molecular Biology National Institute on Aging National Institutes of Health Baltimore MD USA 3. Clinical Investigation National Institute on Aging National Institutes of Health Baltimore MD USA 4. Institute of Biomedical Sciences Federal University of Rio de Janeiro RJ Brazil ISI Correspondence to Dennis D. Taub PhD Laboratory of Immunology Clinical Immunology Section National Institute on Aging-Intramural Research Program NIH Biomedical Research Center 251 Bayview Blvd Room 8C222 Baltimore MD. 21224 USA. Phone 410-558-8181 Fax 410-558-8284 E-mail TaubD@ Received Accepted Published Abstract Age-associated thymic involution is characterized by decreased thymopoiesis adipocyte deposition and changes in the expression of various thymic microenvironmental factors. In this work we characterized the distribution of fat-storing cells within the aging thymus. We found an increase of unilocular adipocytes ERTR7 and CCR5 fat-storing multilocular cells in the thymic septa and parenchymal regions thus suggesting that mesenchymal cells could be immigrating and differentiating in the aging thymus. We verified that the expression of CCR5 and its ligands CCL3 CCL4 and CCL5 were increased in the thymus with age. Hypothesizing that the increased expression of chemokines and the CCR5 receptor may play a role in adipocyte recruitment and or .
