Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk – A Meta-Analysis. | Int. J. Med. Sci. 2010 7 55 International Journal of Medical Sciences 2010 7 1 55-61 Ivyspring International Publisher. All rights reserved Research Paper Association between regulated upon activation normal T cells expressed and secreted RANTES -28C G polymorphism and asthma risk - A Meta-Analysis Qiaoqiao Fang 1 Furu Wang 2 Deyu Zhao1 H 1. Department of Respiratory Medicine Nanjing Children s Hospital Affiliated to Nanjing Medical University Nanjing 210029 China 2. Department of Epidemiology and Biostatistics Cancer Center Nanjing Medical University Nanjing 210029 China Contributed equally. H Corresponding author Dr. Deyu Zhao Department of Respiratory Medicine Nanjing Children s Hospital Affiliated to Nanjing Medical University 72 GuangZhou Rd Nanjing 210029 China. Tel Fax 86-25- 831-17367. E-mail zhaodeyu98@ Received Accepted Published Abstract Regulated upon activation normal T-cell expressed and secreted RANTES is one of the most extensively studied C-C chemokines in allergic inflammation. A growing body of evidence suggests that many cell types present in asthmatic airways have the capacity to generate RANTES which directly supported the potential role of RANTES in asthma. A number of studies have evaluated the functional polymorphism -28C G in the RANTES promoter region which had been found to affect the transcription of the RANTES gene in relation to asthma susceptibility. However the results remain conflicting rather than conclusive. This meta-analysis on 1894 asthma cases and 1766 controls for -28C G from 9 published case-control studies showed that the variant allele -28G was associated with significantly increased risk of asthma GG CG vs CC OR 95 CI without any be-tween-study heterogeneity. In the stratified analysis by asthma type age and ethnicity we found that the increased asthma risk associated with -28G C polymorphism was more evident in children OR 95 CI Asian group OR 95
