Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Serum cholesterol concentration associated with aspirin esterase activity in older people: preliminary data. | Int. J. Med. Sci. 2010 7 90 International Journal of Medical Sciences 2010 7 2 90-93 Ivyspring International Publisher. All rights reserved Short Research Communication Serum cholesterol concentration associated with aspirin esterase activity in older people preliminary data Kazuhiko Kotani 1K1 Russell Caccavello 2 Ricardo Hermo 2 Toshiyuki Yamada 1 Nobuyuki Taniguchi 1 and Alejandro Gugliucci 2 1. Department of Clinical Laboratory Medicine Jichi Medical University Tochigi Japan 2. Glycation Oxidation and Disease Laboratory Touro University-California Vallejo CA USA H Corresponding author Kazuhiko Kotani MD PhD Department of Clinical Laboratory Medicine Jichi Medical University 3311-1 Yakushiji Shimotsuke-City Tochigi 329-0498 Japan. Tel 81-285-58-7386 Fax 81-285-44-9947 E-mail kazukotani@ Received Accepted Published Abstract OBJECTIVE Metabolism of aspirin acetylsalicylic acid commonly used in older people for the prevention of cardiovascular disease is important to the effectiveness of this drug. Whereas part of aspirin hydrolysis occurs in blood there is a paucity of information in regards to circulating aspirin esterase activity in various physiological and pathological conditions. High aspirin esterase activity corresponding to faster aspirin hydrolysis thus aspirin non-responsiveness may occur in cardiovascular disease-prone states. The objective of this study was to investigate the effects of cardio-metabolic variables such as cholesterol on serum aspirin esterase activity in older people who participated in an intervention study on physical activity. METHODS A total of 18 non-medicated subjects 7 men 1 1 women mean age years body mass index kg m2 who completed a 3-month interventional program for a mild-to-moderate increase in physical activity were analyzed. The body mass index plasma glucose serum total cholesterol and aspirin esterase activity were measured in the pre- and post-interventional .
