Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv “Click Chemistry” targeted to αvβ3 integrin for therapy. | Int. J. Med. Sci. 2010 7 326 International Journal of Medical Sciences 2010 7 6 326-339 Ivyspring International Publisher. All rights reserved Research Paper A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv Click Chemistry targeted to avP3 integrin for therapy Klaus Braun1 H Manfred Wiessler1 Rudiger Pipkorn2 Volker Ehemann3 Tobias Bauerle1 Heinz Fleischhacker1 Gabriele Muller4 Peter Lorenz1 Waldemar Waldeck4 1. German Cancer Research Center Dept. of Imaging and Radiooncology INF 280 D-69120 Heidelberg Germany 2. German Cancer Research Center Central Peptide Synthesis Unit INF 580 D-69120 Heidelberg Germany 3. University of Heidelberg Institute of Pathology INF 220 D-69120 Heidelberg Germany 4. German Cancer Research Center Division of Biophysics of Macromolecules INF 580 D-69120 Heidelberg Germany The authors contributed equally to this work H Corresponding author Klaus Braun . German Cancer Research Center DKFZ Dept. of Imaging and Radiooncology Im Neuenheimer Feld 280 D-69120 Heidelberg Germany. Phone 49 6221-42 2495 Fax 49 6221-42 3326 e-mail Received Accepted Published Abstract Clinical experiences often document that a successful tumor control requires high doses of drug applications. It is widely believed that unavoidable adverse reactions could be minimized by using gene-therapeutic strategies protecting the tumor-surrounding healthy tissue as well as the bone-marrow. One new approach in this direction is the use of Targeted Therapies realizing a selective drug targeting to gain effectual amounts at the target site even with drastically reduced application doses. MCF-7 breast cancer cells expressing the avP3 al-pha v beta 3 integrin receptor are considered as appropriate candidates for such a targeted therapy. The modularly composed BioShuttle carrier consisting of different units designed to facilitate the passage across the cell membranes and for subcellular addressing of diagnostic and or .
