Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài:Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers. | Int. J. Med. Sci. 2011 8 387 IVYSPRING iNTErNAToNALI- International Journal of Medical Sciences 2011 8 5 387-396 Research Paper Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers Ruediger Pipkorn1 x Manfred Wiessler2 Waldemar Waldeck3 Peter Lorenz2 Ute Muehlhausen2 Heinz Fleischhacker2 Mario Koch1 Klaus Braun2 1. German Cancer Research Center Central Peptide Synthesis Unit INF 580 69120 Heidelberg Germany 2. German Cancer Research Center Dept. of Imaging and Radiooncology INF 280 69120 Heidelberg Germany 3. German Cancer Research Center Division of Biophysics of Macromolecules INF 580 69120 Heidelberg Germany Ruediger Pipkorn and Mannfred Wiessler have contributed equally to the publication H Corresponding author Dr. Rudiger Pipkorn German Cancer Research Center DKFZ Central Peptide Synthesis Unit Im Neuenheimer Feld 580 D-69120 Heidelberg Germany. Phone 49 6221-42 2847 Fax 49 6221-42 2846 e-mail r. pipkorn@dkfz. de Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License http licenses by-nc-nd . Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. Received Accepted Published Abstract In the near future personalized medicine with nucleic acids will play a key role in molecular diagnostics and therapy which require new properties of the nucleic acids like stability against enzymatic degradation. Here we demonstrate that the replacement of nucleobases with PNA by functional molecules harbouring either a dienophile or a diene reactivity is feasible and confers all new options for functionalization. These newly developed derivatives allow independent multi-ligations of multi-faceted components by use of the inverse Diels Alder technology. The high chemical stability and the ease of synthesis qualify these .
