Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Behavioral and antioxidant activity of a tosylbenz[g]indolamine derivative. A proposed better profile for a potential antipsychotic agent. | Annals of General Hospital Psychiatry Primary research BioMed Central Open Access Behavioral and antioxidant activity of a tosylbenz g indolamine derivative. A proposed better profile for a potential antipsychotic agent Chara A Zika loannis Nicolaou Antonis Gavalas George V Rekatas Ekaterini Tani and Vassilis J Demopoulos Address Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki Thessaloniki 54124 Greece Email Chara AZika - chzika@ Ioannis Nicolaou - Inicolao@ Antonis Gavalas - vdem@ George V Rekatas - vdem@ Ekaterini Tani - vdem@ Vassilis J Demopoulos - vdem@ Corresponding author Published 07 January 2004 Received 29 November 2002 Accepted 07 January 2004 Annals of General Hospital Psychiatry 2004 3 1 This article is available from http content 3 1 1 2004 Zika et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Tardive dyskinesia TD is a major limitation of older antipsychotics. Newer antipsychotics have various other side effects such as weight gain hyperglycemia etc. In a previous study we have shown that an indolamine molecule expresses a moderate binding affinity at the dopamine D2 and serotonin 5-HT1A receptors in in vitro competition binding assays. In the present work we tested its p-toluenesulfonyl derivative TPBIA for behavioral effects in rats related to interactions with central dopamine receptors and its antioxidant activity. Methods Adult male Fischer-344 rats grouped as i Untreated rats TPBIA was administered . in various doses ii Apomorphine-treated rats were treated with apomorphine 1 mg kg-1 . 10 min after the administration of TPBIA. Afterwards the rats were placed individually in the .
