Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inhaled Corticosteroids, Corticosteroid Osteoporosis, and the Risk of Fracture in Chronic Asthma. | Asthma and Therapeutics Inhaled Corticosteroids Corticosteroid Osteoporosis and the Risk of Fracture in Chronic Asthma John H. Toogood MD FRCPC Abstract Current guidelines for the diagnosis and treatment of osteoporosis do not address the risks to bone density and the likelihood of fracture that may be associated with inhaled corticosteroid treatment for asthma. This review outlines an approach to the use of bone densitometry in clinical practice for the diagnosis prevention and treatment of osteoporosis in asthmatic patients receiving inhaled corticosteroid therapy. Diagnosis of Osteoporosis Bone densitometry by dual-energy x-ray absorptiometry DXA allows osteoporosis to be diagnosed and corrective treatment initiated before clinical fractures The hip and lumbosacral spine are the best validated sites for an objective measurement of bone mineral density BMD from which to estimate fracture risk. The degree of risk is estimated to increase to 3-fold for every standard deviation decrease in BMD. To facilitate clinical interpretation of the test result BMD measured in absolute terms is converted to a T-score and or Z-score. The T-score compares the patient s measured BMD with the average value for healthy young adults when their peak bone mass is normally attained about J. H. Toogood Emeritus Professor of Medicine University of Western Ontario Division of Clinical Immunology and Allergy Department of Medicine London Health Sciences Centre London Ontario Correspondence to Dr. John H. Toogood 194 Hunt Club Drive London ON N6H 3Y9 30 years of age . T-score values at or below indicate osteoporosis and a clinically important increase in fracture The Z-score compares the patient s measured BMD with that of a population of healthy persons of the same age and sex as the patient that is it controls for the potentially confounding effects of concurrent reductions in BMD that relate to advancing age. Decisions about the need for preventive or corrective .
