Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Recombinant Therapies in Asthma. | Asthma and Therapeutics Recombinant Therapies in Asthma Donald W. Cockcroft MD FRCPC Abstract Numerous recombinant therapies are being investigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti-immunoglobulin Ig E omal-izumab Xolair markedly inhibits all aspects of the allergen challenge in subjects who have reduction of free serum IgE to undetectable levels. Several clinical studies in atopic asthma have demonstrated benefit by improved symptoms and lung function and a reduction in corticosteroid requirements. Early use in atopic asthmatics may be even more effective. Several approaches target interleukin IL -4. Soluble IL-4 receptor has been shown to effectively replace inhaled corticosteroid further studies are under way. Recombinant anti-IL-5 and recombinant IL-12 inhibit blood and sputum eosinophils and allergen-induced eosinophilia without any effect on airway responsiveness allergen-induced airway responses or allergen-induced airway hyperresponsiveness. Efalizumab a recombinant antibody that inhibits lymphocyte trafficking is effective in psoriasis. A bronchoprovocation study showed a reduction in allergen-induced late asthmatic response and allergen-induced eosinophilia which suggests that it should be effective in clinical asthma. These exciting novel therapies provide not only promise of new therapies for asthma but also valuable tools for investigation of asthma mechanisms. D. W. Cockcroft Department of Medicine University of Saskatchewan Royal University Hospital Saskatoon Saskatchewan Correspondence to Dr. Donald W. Cockcroft Royal University Hospital Division of Respiratory Medicine 103 Hospital Drive Ellis Hall 5th Floor Saskatoon SK S7N 0W8 History As previously reviewed 1 pharmacotherapy for asthma has changed dramatically in the past 100 years. At the turn of the century therapy for acute asthma included mainly narcotics eg heroin morphine and sedatives chloral hydrate agents now .
