Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical Management of Adult Patients with a History of Nonsteroidal Anti-Inflammatory Drug–Induced Urticaria/ Angioedema: Update | ORIGINAL ARTICLE Clinical Management of Adult Patients with a History of Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria Angioedema Update Riccardo Asero MD In the large majority of previous studies patients with a history of acute urticaria induced by nonsteroidal anti-inflammatory drugs NSAIDs seeking safe alternative drugs have undergone tolerance tests uniquely with compounds exerting little or no inhibitory effect on the cyclooxygenase 1 enzyme. In light of recently published studies however this approach seems inadequate and should be changed. The present article critically reviews the clinical management of patients presenting with a history of urticaria induced by a single NSAID or multiple NSAIDs and suggests a simple updated diagnostic algorithm that may assist clinicians in correctly classifying their patients. Key words aspirin drug allergy nonsteroidal anti-inflammatory drug urticaria Nonsteroidal anti-inflammatory drugs NSAIDs are the most frequently prescribed drug class in the world. Their widespread use further increased by the fact that in many countries some very popular compounds such as acetylsalicylic acid ASA propionic acid derivatives or paracetamol acetaminophen are present in over-the-counter drugs is certainly the main cause for the increasing number of adverse reactions induced by these drugs that has been recorded worldwide. Although NSAIDs are generally well tolerated they may induce a large spectrum of adverse reactions some of which are potentially fatal. The most common adverse reactions linked to their inhibitory effects on the cyclooxygenase 1 COX-1 enzyme are gastritis and peptic ulcers. Other adverse reactions include hepatitis and liver toxicity anemia interstitial nephritis erythema multiforme toxic epidermal necrolysis Lyell s syndrome Stevens-Johnson syndrome and cutaneous and or respiratory immediate allergic and pseudoallergic reactions. The term pseudoal-lergic defines reactions characterized by clinical symptoms .
