Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment of Allergic Diseases: Application to Clinical Practice of a New Concept of Mutual Substitutions of Antibody Molecules on the Surface of Mast Cells. | BRIEF COMMUNICATION Treatment of Allergic Diseases Application to Clinical Practice of a New Concept of Mutual Substitutions of Antibody Molecules on the Surface of Mast Cells Kimihiko Okazaki MD PhD rhe concept of whether there are mutual substitutions of antibodies on cell surfaces has not received much attention to date presumably because it does not look important. However it could be far more relevant than first appearance because most if not all allergic diseases could be cured if nonpathogenic antibodies substituted pathogenic antibodies on the surface of mast cells. In 1976 Turton reported that his hay fever had been cured after three time-repeated infections and exterminations of In 1979 Kojima hypothesized in a domestic journal that antihookworm antibodies might have saturated all Fc receptors on Turton s mast If there were only two antibody molecules on a cell their mutual substitution could occur in a probability of 1 2 because an equilibrium state exists between free and cellbound antibodies. If there were three antibody molecules the probability would be 2 3. It follows that when N antibody molecules are present the probability of their mutual substitution is N-1 N. There are numerous antibody molecules bound to mast cells. Therefore the probability N-1 N is virtually equal to 1. A logical conclusion is that mutual substitutions of antibodies do occur on cell surfaces without fail. Supporting the above theory are the results of the following case. In 1995 a 31-year-old woman with an egg allergy was treated with injections with a nonspecific antigen preparation Asthremedin Nippon Zohki Pharmaceutical Company Osaka Japan . Her blood samples were taken before and 4 months after the start of treatment. Ovalbumin and Asthremedin were separately labeled with fluorescence. Aliquots of her blood taken before the treatment were Kimihiko Okazaki Okazaki Medical Clinic Kyoto Japan. Correspondence to Dr. Kimihiko Okazaki Okazaki Medical Clinic
