Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Immunotherapy with Allergen Peptides. | ORIGINAL ARTICLE Immunotherapy with Allergen Peptides Mark Larche PhD Specific allergen immunotherapy SIT is disease-modifying and efficacious. However the use of whole allergen preparations is associated with frequent allergic adverse events during treatment. Many novel approaches are being designed to reduce the allergenicity of immunotherapy preparations whilst maintaining immunogenicity. One approach is the use of short synthetic peptides which representing dominant T cell epitopes of the allergen. Short peptides exhibit markedly reduced capacity to cross link IgE and activate mast cells and basophils due to lack of tertiary structure. Murine pre-clinical studies have established the feasibility of this approach and clinical studies are currently in progress in both allergic and autoimmune diseases. Key words allergy epitope IL-10 immunological tolerance immunotherapy peptide regulatory T cell T cell Specific allergen immunotherapy SIT is disease modifying and efficacious. However the use of whole-allergen preparations is associated with frequent allergic adverse events during treatment. Many novel approaches are being designed to reduce the allergenicity of immunotherapy preparations while maintaining immunogenicity. One approach is the use of short synthetic peptides that represent dominant T-cell epitopes of the allergen. Short peptides exhibit markedly reduced capacity to cross-link immunoglobulin Ig E and activate mast cells and basophils owing to a lack of tertiary structure. Murine preclinical studies have established the feasibility of this approach and clinical studies are currently in progress in both allergic and autoimmune diseases. In non-allergic individuals allergen exposure can be associated with a failure to mount a detectable immune response. In those individuals who do make an immune response it is characterized by non-inflammatory regulatory elements such as interleukin IL -10-secreting T The reasons why some individuals suffer from
